1TL8 PDB NFT

Human DNA topoisomerase I (70 kDa) in complex with the indenoisoquinoline AI-III-52 and covalent complex with a 22 base pair DNA duplex

MOLNFT AF v1 smart contract in GenesisL1 blockchain:

0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba

IPFS of NFT metadata:

bafybeif3arleloybwjfllnhibpnfsshqv5xw3jaq7h4loz3vx7cwn4ytk4/metadata.json

IPFS of structure file:

bafybeihnon37ek2gxblinfdxrn2dsdt5z5ofdyojrssgmxsucrvl6lkdbu/1tl8.pdb

MOLNFT PDB v1

NFT id:
22949
PDB ID:
1TL8
Name:
Human DNA topoisomerase I (70 kDa) in complex with the indenoisoquinoline AI-III-52 and covalent complex with a 22 base pair DNA duplex
Keywords:
ISOMERASE/DNA
Experimental Method:
X-RAY DIFFRACTION
Resolution:
3.10

NFT data

MolNFT PDB v1 is The Protein Data Bank database (URL: https://rcsb.org) of protein structures minted as ERC-721 NFT tokens on GenesisL1 blockchain for public free use, research and entertainment:

H.M. Berman, J. Westbrook, Z. Feng, G. Gilliland, T.N. Bhat, H. Weissig, I.N. Shindyalov, P.E. Bourne.
(2000) The Protein Data Bank Nucleic Acids Research, 28: 235-242.

MOLNFT 1TL8 research and analysis (ICN3D with VR)

FASTA sequences

>1tl8_B mol:na length:10 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3'
AAAAAGACTT
>1tl8_C mol:na length:12 5'-D(*(TPC)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3'
CGAAAAATTTTT
>1tl8_D mol:na length:22 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*GP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3'
AAAAATTTTTCGAAGTCTTTTT
>1tl8_A mol:protein length:592 DNA topoisomerase I
KKPKNKDKDKKVPEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKCDFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQTKIDAKKEQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF

References and links

Current molecular structure file and data about current molecular structure file and NFT token based on it with
PDBID: 1TL8
TITLE: Human DNA topoisomerase I (70 kDa) in complex with the indenoisoquinoline AI-III-52 and covalent complex with a 22 base pair DNA duplex
DOI: 10.1021/jm050076b
AUTHORS: Ioanoviciu, A., Antony, S., Pommier, Y., Staker, B.L., Stewart, L., Cushman, M.
ACCESSION DATE: 06/09/04
Obtained at RCSB PDB https://rcsb.org
RCSB Link: https://www.rcsb.org/structure/1TL8